Table 1 Clinical characteristics of the first case/control study in Southern Chinese population.

From: The association of telomere attrition with first-onset stroke in Southern Chinese: a case-control study and meta-analysis

Characteristics

Control subjects (n = 616)

Stroke patients

Total cases (n = 543)

Hemorrhagic stroke (n = 94)

Atherothrombotic stroke (n = 224)

Lacunar infarction (n = 225)

Age, years

63.6 ± 11.9

65.9 ± 12.2**

63.5 ± 13.8

65.9 ± 11.6*

70.0 ± 11.9**

Male, n (%)

284 (46.1%)

336 (56.3%)**

54 (36.5%)

121 (54.0%)*

130 (57.8%)*

Body mass index, kg/m2

24.00 ± 2.28

23.90 ± 2.89

23.86 ± 2.91

24.18 ± 2.97

23.66 ± 2.77

Systolic BP, mmHg

136 ± 10

146 ± 23**

164 ± 28**

143 ± 19**

143 ± 22**

Diastolic BP, mmHg

83 ± 8.23

88 ± 14**

99 ± 18**

86 ± 11**

86 ± 12**

Glucose, mmol/L

5.41 ± 1.59

6.19 ± 2.52**

6.82 ± 3.38**

6.31 ± 2.17**

5.81 ± 2.37*

Total cholesterol, mmol/L

5.16 ± 0.98

4.64 ± 1.99**

4.91 ± 1.36*

4.68 ± 2.64**

4.49 ± 1.35**

Triglycerides, mmol/L

1.40 (0.95–1.77)

1.31 (0.91–1.92)

1.09 (0.82–1.80)*

1.42 (1.0–2.13)

1.31 (0.93–1.80)

Plasma uric acid, µmol/L

280.79 ± 61.89

306.29 ± 103.76**

336.07 ± 129.00**

303.06 ± 100.01**

296.79 ± 92.94*

Smoking, n (%)

36 (5.8%)

145 (26.7%)**

30 (20.3%)**

52 (23.2%)**

63 (28.0%)**

Alcohol intake, n (%)

47 (7.6%)

120 (22.1%)**

28 (18.9%)**

48 (21.4%)**

44 (19.6%)**

History of hypertension, n (%)

313 (50.8%)

324 (59.7%)*

69 (46.6%)**

138 (61.6%)*

118 (52.4%)

History of diabetes, n (%)

102 (16.6%)

110 (20.3%)

17 (11.5%)

58 (25.9%)*

36 (16.0%)

History of CHD, n (%)

2 (0.3%)

77 (14.2%)**

13 (8.8%)**

38 (17.0%)**

26 (11.6%)**

Telomerase length (Ln-T/S ratio)

1.75 ± 0.71

1.65 ± 0.95

1.62 ± 1.04

1.45 ± 0.95**

1.87 ± 0.87*

  1. Abbreviations: BP, blood pressure; CHD, coronary heart disease. Telomere length is expressed as a relative telomere repeat copy/single-copy gene (T/S) ratio, and Ln(T/S) is natural logarithm transformed leucocyte telomere length T/S ratio. Values are mean ± SD, number (percentage), or median (interquartile range).
  2. *P < 0.05, **P < 0.01, stroke patients vs. control subjects. The two-sample t-test was used for comparison of continuous variables, the chi-square test for categorical variables, and the Mann–Whitney U test for Triglycerides and relative T/S ratio.
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