Table 2 Associations between leucocyte telomere length and stroke in the first case/control study of Southern Chinese population.

From: The association of telomere attrition with first-onset stroke in Southern Chinese: a case-control study and meta-analysis

Variables

Highest tertile (>2.06)

Middle tertile (1.52–2.06)

Lowest tertile (<1.52)

P trend

Per 1-S.D. decrease in Ln-transformed telomere length

P

Controls (n = 616)

206

205

205

   

Total cases (n = 543)

179

147

217

   

ORs (95% CI)

 No adjustment

1.0

0.83 (0.62–1.11)

1.22 (0.92–1.61)

0.03

1.11 (1.00–1.22)

0.048

 Model I

1.0

0.79 (0.55–1.13)

1.04 (0.74–1.47)

0.23

1.07 (0.95–1.21)

0.27

 Model II

1.0

0.82 (0.56–1.20)

1.05 (0.72–1.51)

0.38

1.07 (0.94–1.22)

0.33

Hemorrhagic stroke (n = 94)

33

21

40

   

ORs (95% CI)

 No adjustment

1.0

0.64 (0.36–1.14)

1.22 (0.74–2.01)

0.08

1.16 (0.96–1.42)

0.13

 Model I

1.0

0.82 (0.34–1.97)

0.91 (0.40–2.07)

0.91

1.08 (0.80–1.46)

0.61

 Model II

1.0

0.73 (0.27–1.97)

0.89 (0.36–2.20)

0.82

1.05 (0.75–1.46)

0.78

Atherothrombotic stroke (n = 224)

51

67

106

   

ORs (95% CI)

 No adjustment

1.0

1.32 (0.87–1.99)

2.09 (1.42–3.07)

0.001

1.39 (1.21–1.60)

<0.001

 Model I

1.0

1.47 (0.90–2.40)

2.39 (1.50–3.80)

0.001

1.49 (1.26–1.75)

<0.001

 Model II

1.0

1.43 (0.84–2.41)

2.33 (1.42–3.83)

0.003

1.48 (1.24–1.76)

<0.001

Lacunar infarction (n = 225)

95

59

71

   

ORs (95% CI)

 No adjustment

1.0

0.62 (0.43–0.91)

0.75 (0.52–1.08)

0.04

0.87 (0.75–1.00)

0.053

 Model I

1.0

0.50 (0.31–0.79)

0.51 (0.32–0.80)

0.003

0.74 (0.61–0.88)

0.001

 Model II

1.0

0.52 (0.31–0.85)

0.49 (0.30–0.81)

0.007

0.72 (0.59–0.88)

0.001

  1. The cut-off values of tertile of leucocyte telomere length (relative T/S ratio) were derived from the control group, with <1.52 for the lowest, 1.52–2.06 for the middle and >2.06 for the highest tertile (as the reference). OR (95% CI) was obtained with multivariate logistic regression analysis.
  2. Model I: adjustment for age, gender, systolic and diastolic BP, fasting glucose, total cholesterol, triglycerides, plasma uric acid, and body mass index.
  3. Model II: adjustment for the covariates mentioned above plus smoking status, alcohol intake, history of hypertension, diabetes, and previous CHD.
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