Table 3 Stratified association analysis of per 1-S.D. decrease of ln-transformed telomere length in stroke subtypes.

From: The association of telomere attrition with first-onset stroke in Southern Chinese: a case-control study and meta-analysis

Variables

Atherothrombotic stroke

Lacunar stroke

Cases/control

OR (95% CI)

P*

P interaction †

Cases/control

OR (95% CI)

P*

P interaction †

Gender

Male

121/284

1.46 (1.13–1.89)

0.004

0.06

130/284

0.68 (0.52–0.89)

0.005

0.40

Female

103/332

1.43 (1.11–1.85)

0.005

 

95/332

0.70 (0.52–0.94)

0.019

 

Age

≤50

23/99

1.66 (0.88–3.13)

0.12

 

20/99

0.79 (0.37–1.70)

0.55

0.09

51–60

57/134

1.59 (1.15–2.19)

0.005

0.07

42/134

0.75 (0.50–1.12)

0.16

 

≥60

144/383

1.38 (1.10–1.73)

0.006

 

163/383

0.67 (0.53–0.85)

0.001

 

BMI

<25

144/464

1.44 (1.14–1.82)

0.002

0.25

163/464

0.58 (0.45–0.75)

<0.001

0.09

≥25

80/152

1.66 (1.25–2.20)

<0.001

 

62/152

1.12 (0.80–1.58)

0.51

 

Smoking

No

172/580

1.48 (1.22–1.80)

<0.001

0.81

162/580

0.69 (0.55–0.86)

0.001

0.92

Yes

52/36

1.40 (0.91–2.14)

0.12

 

63/36

0.72 (0.45–1.13)

0.15

 

Alcohol intake

No

176/569

1.41 (1.17–1.71)

<0.001

0.79

181/569

0.70 (0.56–0.86)

0.001

0.82

Yes

48/47

1.50 (0.93–2.41)

0.10

 

44/47

0.74 (0.47–1.16)

0.10

 

Hypertension

No

86/303

1.86 (1.42–2.45)

<0.001

0.001

107/303

0.59 (0.43–0.81)

0.001

0.055

Yes

138/313

1.35 (1.06–1.72)

0.016

 

118/313

0.83 (0.63–1.10)

0.19

 

Diabetes

No

166/514

1.40 (1.14–1.71)

0.001

0.55

189/514

0.67 (0.54–0.83)

0.001

0.37

Yes

58/102

1.83 (1.22–2.74)

0.004

 

36/102

0.97 (0.55–1.72)

0.91

 
  1. *OR (95% CI) and P values were obtained with multivariate logistic regression analysis after adjustment for conventional vascular risk factors, including age, gender, systolic and diastolic BP, fasting glucose, total cholesterol, triglycerides, plasma uric acid, body mass index, smoking status, alcohol intake, history of hypertension, diabetes and previous CHD, except for the stratification variable. †Pinteraction was obtained by evaluating interaction terms.
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