Figure 6 | Scientific Reports

Figure 6

From: Thyroid stimulating hormone stimulates the expression of glucose transporter 2 via its receptor in pancreatic β cell line, INS-1 cells

Figure 6

The effect of TSH on the expression of glucokinase and insulin in pancreatic β cells. TSH increases the abundance of glucokinase (GK) protein (a) and insulin (b) in a dose-dependent manner. The ratio of GK or insulin to GAPDH is shown as a percentage of the control ratio. Full-length blots are presented in Supplementary Figure 3. c, e and g, glucose-stimulated insulin secretion (GSIS) in INS-1 cells treated with TSH (c) or SB + TSH (g) or in pancreatic islets treated with TSH (e). d, f and h, fold of insulin secretion from low glucose (3.3 mM) to high glucose (16.7 mM) in INS-1 cells treated with TSH (d) or SB + TSH (f) or in pancreatic islets treated with TSH (f). A graph showing the mean ± SEM (n = 3) of separate experiments for each treatment group is indicated. The *denotes a significant difference (P < 0.05) compared to 0.

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