Figure 4
The effect of exosome-mimetic NVs on liver regeneration in vivo. (A) Immediately and every 24 h after hepatectomy, mice were treated with PBS (control) or 100 μg of exosome-mimetic NVs through intravenous injection, and liver regeneration was determined by calculating the liver-to-body weight ratio. (B) Representative livers from mice treated with PBS vehicle or exosome-mimetic NVs after PH, indicating the difference in liver size. (C) The effect of exosome-mimetic NVs in mice without partial hepatectomy. The mice were treated with 100 μg of exosome-mimetic NVs via intravenous injection every 24 h. (D) Typical images of Ki67 staining of livers from mice without partial hepatectomy. The mice were treated with 100 μg of exosome-mimetic NVs via intravenous injection every 24 h. (E) Liver-to-body weight ratio 2 days after PH. a, treatment with exosome-mimetic NVs isolated from mouse livers 2 days after PH. b, treatment with exosome-mimetic NVs isolated from normal mouse livers. (F,G) Serum AST and ALT levels in mice treated with PBS vehicle or exosome-mimetic NVs after PH. (H) Typical images of Ki67 staining of livers from mice treated with PBS vehicle or exosome-mimetic NVs at different time points. NS not significant; *P < 0.05; **P < 0.01.
