Figure 3
From: Nanodiamonds-induced effects on neuronal firing of mouse hippocampal microcircuits
MEA recordings of hippocampal neurons activity without FNDs and after FNDs seeding. (a–c) Representative traces of spontaneous firing at 18 DIV (data from 3 representative MEA channels) under control conditions (CTRL), without FNDs (a), with FNDs seeded at 7 DIV (b) and at 14 DIV (c). Insets: higher magnification of single spikes and bursts. (d) Bar graphs of the mean frequency measured at 18 DIV without FNDs (CTRL, white) and after FNDs administration at 7 DIV (grey) and 14 DIV (black). (e) Bar graphs of mean frequency of the spontaneous activity measured at 11 DIV without FNDs (CTRL) and after FNDs administration at 7 DIV. (f) Bar graphs of mean frequency of the spontaneous activity measured at 14 DIV without FNDs (CTRL) and after FNDs administration at 7 DIV. (g) Bar graphs of mean number of bursts and mean burst duration without FNDs (CTRL), and after FNDs administration at 7 and 14 DIV. (h) Bar graphs of mean burst duration (s) without (CTRL) and after FND seeding at 7 and 14 DIV.
