Figure 1 | Scientific Reports

Figure 1

From: Decreased TESK1-mediated cofilin 1 phosphorylation in the jejunum of IBS-D patients may explain increased female predisposition to epithelial dysfunction

Figure 1The alternative text for this image may have been generated using AI.

Proteomic signature of IBS-D patients. (A) DIGE analysis of protein extracts from jejunal mucosal biopsies. Heatmap for the 95 identified spots differentially expressed in IBS-D samples (n = 4) compared to healthy control samples (n = 4). Colors represent relative expression levels on a color scale (green: low/red: high). A total of 1200 spots were analyzed. 139 showed a >1.3-fold change and, from those, 95 spots were identified. Thirty-seven spots showed increased intensity (red-encircled spots), whereas 58 spots showed decreased intensity (green-encircled spots). (B) Annotations for the top ten up- and down-regulated spots identified in IBS-D vs. healthy control samples. Uniprot accession number, protein symbols and name, and their fold change expression in IBS-D with respect to healthy controls are shown.

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