Figure 2 | Scientific Reports

Figure 2

From: Decreased TESK1-mediated cofilin 1 phosphorylation in the jejunum of IBS-D patients may explain increased female predisposition to epithelial dysfunction

Figure 2The alternative text for this image may have been generated using AI.

Relationships between differentially expressed proteins in the highest scored network generated by IPA where CFL1 has a central role. (A) Protein-protein interaction network showing the differentially expressed proteins in IBS-D compared to healthy controls and Canonical Pathways (CP) and Biological Functions (Fx) associated to the proteins belonging to this particular network. The intensity of the node color indicates the degree of upregulation (red) or down regulation (green). Genes in uncolored nodes were not identified as differentially expressed in our proteomic study and were integrated into the computationally generated networks on the basis of the evidence stored in the IPA knowledge data base indicating relevance for this network. (B) Summary of the actin depolymerization pathway regulated by CFL1.

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