Table 2 Canonical signaling pathways most significantly associated with IBS-D protein expression profile.
Ingenuity canonical pathways | Significance (P-value) | Ratio* | Molecules |
|---|---|---|---|
LPS/IL1 mediated Inhibition of RXR funtion | 0.0003 | 2.94E-02 | ALDH1B1, SULT1A3/SULT1A4, GSTT1, ALDH1A1, FABP1, SULT2A1 |
Mitochondrial Dysfunction | 0.0003 | 3.94E-02 | SDHA, PRDX3, SOD2, NDUFV2, PARK7 |
Regulation of Actin-based Motility by Rho | 0.0007 | 4.55E-02 | ACTR3, CFL1, ACTA2, ACTA1 |
VEGF Signaling | 0.0008 | 4.26E-02 | YWHAE, GRB2, ACTA2, ACTA1 |
Clathrin-mediated Endocytosis Signaling | 0.0009 | 3.01E-02 | ACTR3, TF, GRB2, ACTA2, ACTA1 |
RhoA Signaling | 0.002 | 3.81E-02 | ACTR3, CFL1, ACTA2, ACTA1 |
Bile acid biosynthesis | 0.002 | 6.12E-02 | ALDH1B1, AKR1A1, ALDH1A1 |
PI3K/AKT Signaling | 0.002 | 3.03E-02 | YWHAE, GRB2, YWHAB, YWHAZ |
Actin Cytoskeleton Signaling | 0.003 | 2.21E-02 | ACTR3, CFL1, ACTA2, ACTA1 |
Caveolar-mediated Endocytosis Signaling | 0.005 | 3.70E-02 | ALB, ACTA2, ACTA1 |
Protein Ubiquitination Pathway | 0.008 | 1.85E-02 | PSMB3, PSME1, HSPA1A/HSPA1B, PSMB2, HSPA9 |
Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes | 0.01 | 3.19E-02 | ACTR3, ACTA2, ACTA1 |
Integrin Signaling | 0.01 | 1.99E-02 | ACTR3, GRB2, ACTA2, ACTA1 |
Glucocorticoid Receptor Signaling | 0.03 | 1.48E-02 | HSPA1A/HSPA1B, GRB2, ANXA1, HSPA9 |
Ephrin Receptor Signaling | 0.05 | 1.55E-02 | ACTR3, CFL1, GRB2 |
