Figure 1
From: A computationally driven analysis of the polyphenol-protein interactome
Forty-three distinct substructures of polyphenols produce 5 classes: (i) flavonoids (9 subclasses: anthocyanins, chalcones, dihydrochalcones, dihydroflavonols and flavanone, flavone and flavonol, isoflavonoid), (ii) lignans, (iii) phenolic acids (hydroxybenzoic acids, hydroxycinnamic acids, hydroxyphenylacetic acids, hydroxyphenylpropionic acids, hydroxyphenylpentanoic acids), (iv) stilbenes, and (v) other polyphenols (alkylmethoxyphenols and hydroxyphenylpropenes and alkylphenols, curcuminoids, furanocoumarins, hydroxybenzaldehydes and hydroxycinnamaldehydes, hydroxybenzoketones, tyrosols). Some polyphenol subclasses have several scaffolds (e.g., phenolic acids) to describe ortho-, para-, and meta- substitutions, while several polyphenol subclasses (e.g., flavonols and flavones) have a single substructure. Some substructures include more than one subclass (redundancy). Non-polyphenolic metabolites (6th class) could not be queried, as not having fixed structural features.
