Table 1 In vivo echocardiography cardiac functional and structural characteristics in diabetic male & female mice.

From: Diastolic dysfunction is more apparent in STZ-induced diabetic female mice, despite less pronounced hyperglycemia

 

Male

Female

Ctrl

Diabetes

Ctrl

Diabetes

E wave (mm/s)

504 ± 39

412 ± 39

454 ± 55

521 ± 82

A wave (mm/s)

278 ± 36

245 ± 28

226 ± 30

352 ± 72

E′ wave (mm/s)

29.0 ± 2.2

21.8 ± 2.5*

28.7 ± 1.3

21.7 ± 2.0*

A′ wave (mm/s)

23.4 ± 2.0

23.1 ± 1.5

22.6 ± 4.2

30.2 ± 6.3

End diastolic vol. (mL)

134 ± 8.8

154 ± 8.0*

121 ± 3.5

137 ± 5.8

Heart rate (bpm)

478 ± 23

437 ± 11

486 ± 15

460 ± 18

Stroke vol. (mL)

87.3 ± 6.6

96.7 ± 4.1

80.7 ± 2.2

84.6 ± 3.3#

Cardiac output (mL/s)

0.71 ± 0.05

0.71 ± 0.03

0.66 ± 0.02

0.65 ± 0.05

IVSs (mm)

1.32 ± 0.04

1.17 ± 0.03*

1.40 ± 0.03#

1.22 ± 0.04*

LVPWs (mm)

1.30 ± 0.04

1.10 ± 0.04*

1.17 ± 0.03#

0.91 ± 0.05*#

Relative wall thickness (ratio)

0.53 ± 0.02

0.42 ± 0.01*

0.51 ± 0.01

0.40 ± 0.01*

Ventricular weight (mg)

130 ± 4.0

115 ± 3.2*

111 ± 4.2#

95.9 ± 2.9*#

Heart weight/body weight (mg/g)

4.72 ± 0.1

4.71 ± 0.1

4.99 ± 0.1

4.87 ± 0.1

  1. Mitral valve flow velocity, early ventricular filling phase (E wave) and during atrial contraction (A wave); mitral valve tissue movement velocity, early ventricular filling phase (E′ wave) and during atrial contraction (A′ wave), interventricular septal wall thickness at end systole (IVSs), left ventricular posterior wall thickness at end systole (LVPWs), relative wall thickness (RWT). Dissected ventricular weight (left and right ventricle combined) and heart weight normalized to body weight. Data are presented as mean ± sem. n = 5/group (Doppler parameters), n = 12–16/group (M-mode parameters). *p < 0.05 vs Ctrl, #p < 0.05 vs male, 2-way ANOVA, annotated with LSD post hoc analyses.
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