Figure 2 | Scientific Reports

Figure 2

From: Epothilone B Speeds Corneal Nerve Regrowth and Functional Recovery through Microtubule Stabilization and Increased Nerve Beading

Figure 2

Systemic administration of EpoB does not influence the sensitivity or subbasal nerve density under steady conditions. (A) At days 2, 4, and 6 after administration of i.p. EpoB, the corneal sensitivity levels were measured with a Cochet-Bonnet esthesiometer and compared amongst the EpoB, vehicle, and normal groups. (B) Photos of complete corneal nerves stained for β-III tubulin were acquired using a DeltaVision Elite high-resolution microscope at day 6 post-i.p. injection of EpoB. (C) Changes in the total length and total area of nerve fibers of the central test region (Fig. 10B) in the EpoB, control, and vehicle groups after the administration of i.p. EpoB. The results are presented as the mean ± SD. A factorial design ANOVA was performed to analyze the overall differences between the two groups, and Student’s t-test was used to compare the differences between the groups by time point. *P < 0.05, **P < 0.01; n = 6 corneas/group. N.S. = not significant by Student’s t-test.

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