Table 1 Pharmacokinetic parameters of EpoB in normal mice after intraperitoneal injection of EpoB solution (1 mg/kg).

From: Epothilone B Speeds Corneal Nerve Regrowth and Functional Recovery through Microtubule Stabilization and Increased Nerve Beading

Organ

Parameters

tmax

cmax

t1/2

AUC0-t

KP

Units

h

ng/g (ml)

h

ng/g (ml)/h

Cornea

6

148.65 ± 19.86

66.71

8827.77

43.72

Trigeminal ganglion

6

122.96 ± 18.61

46.98

12114.19

60.00

Plasma

12

2.82 ± 0.54

60.17

201.90

1.00

Spinal cord

24

14.07 ± 2.76

485.35

1657.66

8.21

Brain

24

11.77 ± 2.27

447.74

1325.48

6.57

Spleen

6

1174.87 ± 226.75

20.84

29958.27

148.38

Heart

6

384.98 ± 76.23

21.42

11291.44

55.93

Lung

6

515.53 ± 102.07

22.79

13381.47

66.28

Liver

6

196.86 ± 36.42

22.85

5020.40

24.87

Kidney

6

891.51 ± 162.26

20.25

39923.10

197.73

  1. Kp = AUC0-torgan/AUC0-tplasma; ng/g for tissues, ng/ml for plasma.
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