Table 3 Comparison of outcomes among adults with type 1 diabetes in real clinical trials.
Outcomes | 75 g carbohydrate meal (n = 10) | 45 g carbohydrate meal (n = 10) | ||||
|---|---|---|---|---|---|---|
Adequate carbohydrate estimation | Overestimated carbohydrate content | P-Value | Adequate carbohydrate estimation | Overestimated carbohydrate content | P-Value | |
Median [IQR] | Median [IQR] | Median [IQR] | Median [IQR] | |||
% Time <4.0 mmol/L | 0 [0–0] | 0 [0–0] | 0.47 | 0 [0–0] | 0 [0–0] | 0.31 |
Hypoglycemic events | 0 | 1 | — | 0 | 2 | — |
Starting glucose, mmol/L | 8.7 [7.3–10.8] | 8.0 [6.7–9.8] | 0.48 | 7.3 [6.7–11.0] | 9.0 [8.2–10.3] | 0.66 |
Mean glucose, mmol\L | 11.1 [8.6–13.6] | 10.2 [8.0–11.9] | 0.18 | 10.3 [9.0–12.2] | 9.7 [7.5–13.1] | 0.21 |
% Time 4–10 mmol/L | 31 [15–71] | 45 [28–88] | 0.44 | 46 [6–60] | 53 [10–76] | 0.22 |
% Time >10.0 mmol/L | 69 [29–89] | 54 [9–72] | 0.29 | 54 [40–94] | 44 [6–90] | 0.14 |
Peak glucose, mmol/L | 14.6 [11.8–18.7] | 13.3 [10.2–14.9] | 0.15 | 13.7 [11.8–18.7] | 13.7 [9.8–15.7] | 0.15 |
Time to peak, minutes | 93 [70–114] | 125 [78–154] | 0.17 | 108 [95–120] | 80 [70–116] | 0.72 |
Insulin bolus, units | 8.1 [7.3–9.1] | 9.2 [8.2–9.6] | 0.03 | 4.8 [3.7–5.6] | 8.4 [7.2–10.4] | <0.001 |
Basal insulin infusion, units | 4.2 [3.9–5.3] | 4.3 [3.1–5.4] | 0.60 | 5.7 [4.1–7.4] | 4.3 [2.8–5.2] | 0.06 |
Glucagon delivery, mg | 2.9 [0–5.8] | 1.0 [0–4.5] | 0.91 | 0 [0–4.8] | 0.5 [0–5.9] | 0.55 |
