Figure 2
Protein biomarker variation. (a) Intraclass correlation coefficients (ICCs), i.e. proportion of inter-individual variance of total variance, for each protein calculated based on within- and between-individual variances estimated in linear mixed models including case-status, age, sex, BMI, and all lifestyle behavior variables as fixed factors, and subject and case-set as random factors. Proteins with high ICC vary less within, and more between participants, whereas proteins with low ICC vary less between and more within participants. (b) Protein variance explained (Rm2) by each lifestyle behavior variable. Calculated as the change in Rm2 by adding the variable to a linear mixed model including case-status, age, and sex as fixed factors, and subject and case-set as random factors.
