Table 2 Statistically significant associations between plasma protein levels and lifestyle behaviors.

From: Targeted plasma proteomics identifies a novel, robust association between cornulin and Swedish moist snuff

Variable

Protein

Estimate

Beta (SE)a

Pb

Rm2 (%)c

Physical activity (1–5, ranging from none to exercise ≥3 times a week)

TNFBd

Per unit increase

0.19 (0.04)

8.5*10−6

5

MCP-2d

Per unit increase

0.17 (0.04)

9.1*10−5

4

CXCL10d

Per unit increase

0.16 (0.04)

1.5*10−4

3

Smoking (vs. non-smokers)

CXCL17e

Smokers

0.75 (0.14)

5.2*10−8

10

CXCL17e

Ex-smokers

0.12 (0.13)

  

SCFd,e

Smokers

−0.64 (0.16)

1.7*10−4

9

SCFd,d

Ex-smokers

−0.20 (0.14)

  

MSLNe

Smokers

0.54 (0.13)

2.5*10−9

7

MSLNe

Ex-smokers

−0.10 (0.12)

  

WFDC2e

Smokers

0.37 (0.15)

2.6*10−4

4

WFDC2e

Ex-smokers

−0.12 (0.13)

  

IL-12Bd

Smokers

−0.36 (0.14)

4.1*10−5

3

IL-12Bd

Ex-smokers

0.13 (0.12)

  

Snus (vs. non-users)

CRNNe

User

1.22 (0.18)

8.5*10−10

23

CRNNe

Ex-user

0.16 (0.29)

  

Beer intake, 2.8–3.5% alc/vol (vs. zero intake)

hK11e

<Median intake

−0.55 (0.15)

2.3*10−4

2

hK11e

≥Median intake

−0.75 (0.18)

  

Beer intake, ≥4.5% alc/vol (vs. zero intake)

Furine

<Median intake

0.08 (0.16)

2.2*10−4

2

Furine

≥Median intake

0.54 (0.18)

  

Wine intake (vs. zero intake)

ICOSLGe

<Median intake

−0.74 (0.17)

1.4*10−5

7

ICOSLGe

≥Median intake

−0.32 (0.21)

  

IFN-gamma-R1e

<Median intake

−0.47 (0.15)

9.3*10−5

4

IFN-gamma-R1e

≥Median intake

−0.01 (0.18)

  

Unhealthy lifestyle (0–4, score ranging from healthy to unhealthy)

ESM-1e

Per unit increase

−0.37 (0.07)

2.9*10−7

10

FASLGe

Per unit increase

−0.27 (0.07)

8.8*10−5

5

SEZ6Le

Per unit increase

−0.26 (0.07)

1.9*10−4

5

MSLNe

Per unit increase

0.25 (0.06)

5.4*10−5

4

  1. SE: standard error. R m 2: variance explained by fixed factors.
  2. aRegression coefficient from linear mixed models interpreted as standard deviation difference in protein levels compared to exposure reference group (categorical exposures) or per exposure unit increase in (for continuous exposures), adjusted for case status, age, sex, BMI, smoking, and total alcohol intake as fixed factors and participant and case set as random factors.
  3. bBonferroni-adjusted threshold: 0.05/160 = 3.125*10−4.
  4. cProtein variance explained (Rm2) by each lifestyle behavior variable. Calculated as the change in Rm2 by adding the variable to a linear mixed model including case-status, age, and sex as fixed factors, and subject and case-set as random factors.
  5. dInflammation panel.
  6. eOncology II panel.
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