Table 3 Replication of the CRNN-snus association in the independent NSPHS cohort.

From: Targeted plasma proteomics identifies a novel, robust association between cornulin and Swedish moist snuff

 

VIP (n = 133)

Replication NSPHS (n = 501)

nbaseline/nrepeat

Beta (SE)a

P

n

Beta (SE)b

P

Snus usage

Non-user

91/89

ref

 

420

ref

 

Current user

29/32

1.22 (0.18)

8.5*10−10

81

1.25 (0.12)

<2*10−16

Ex-user

13/11

0.14 (0.29)

  

—

—

  

R m 2 = 23%

  

R m 2 = 18%

 

Snus dose

Per 1 pack/week

 

—

—

 

0.22 (0.03)

36*10−15

  

—

  

R2 = 12%

 
  1. VIP: Västerbotten Intervention Programme. NSPHS: Northern Sweden Population Health Study. SE: standard error. R m 2: variance explained by fixed factors. R2: variance explained.
  2. aRegression coefficient from linear mixed models interpreted as standard deviation difference in CRNN to reference group (Non-snus users), adjusted for case status, age, sex, BMI, smoking, and total alcohol intake as fixed factors and participant and case set as random factors.
  3. bRegression coefficient from linear regression interpreted as standard deviation difference in CRNN to reference group (Non-snus users) or change per 1 pack of snus/day, adjusted for age, sex, BMI, smoking, and total alcohol intake.
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