Figure 1

PLS-CA analysis of plasma samples. Score plots, PC1 vs PC2, and corresponding confusion matrices. In the score plot, each dot represents a different plasma sample. Green dots: DS samples; purple dots: healthy controls. All samples (DS, n = 41; CTRL, n = 25). (A) 1Dpresat CPMG spectra; discrimination accuracy: 79.1% (95% CI, 78.6–79.6%); sensitivity: 82.0% (95% CI, 81.3–82.4%); specificity: 75.0% (95% CI, 74.5–78.9%). (B) 1Dpresat NOESY spectra; discrimination accuracy: 83.4% (95% CI, 83.0–83.8%); sensitivity: 85.7% (95% CI, 85.2–86.2%); specificity: 80.0% (95% CI, 79.0–80.3%). Samples from fasting subjects (DS, n = 25; CTRL, n = 21). (C) 1Dpresat CPMG spectra; discrimination accuracy: 81.5% (95% CI, 80.9–82.0%); sensitivity: 83.9% (95% CI, 83.2–84.6%); specificity: 78.6% (95% CI, 77.8–79.5%). (D) and 1Dpresat NOESY spectra; discrimination accuracy: 87.1% (95% CI, 86.7–87.6%); sensitivity: 90.3% (95% CI, 89.8–90.9%); specificity: 83.3% (95% CI, 82.5–84.1%).