Figure 2
Early transcriptional response to rotenone treatment of dopamine containing cells. GO analyses of genes that were upregulated (A) or downregulated (B) in dopamine containing cells in response to rotenone treatment. Clustering was performed with the DAVID program package68. Functional categories overrepresented in the lists of genes differentially expressed in rotenone treated flies identified by DAVID (Table 1, p < 0.05). (C) Fold changes for genes associated with the GO term regulation of apoptosis (D) Oxidative phosphorylation (E) neurotransmitter secretion (F) ageing. Error bars represent SEM. Damm: Death associated molecule related to Mch2, Dcp-1: Death caspase 1, BI-1: Bax Inhibitor 1, Jafrac2: Thioredoxin peroxidase 2, th: thread, PDCD-5: Programmed cell death 5, Hsp60D, out: Outsiders, sox15: Sox box protein 15, Prx2540-2: Peroxiredoxin 2540-2, Cyp6a2, Cyp12a5, Cyp12a4: Cytochrome p450-6a2, 12a4, 12a5, respectively, Su(Tpl): CoVIIc: Cytochrome c oxidase subunit VIIc, CG6463, Csp: Cysteine string protein, Fas2: Fasciclin2, Frq1: Frequenin 1, Hsc70-4: Heat shock protein cognate 4, Sap47: Synapse associated protein 47kD, Syx1A: Syntaxin 1A, EndoA: Endophilin A, Usnp: Ubisnap, clumsy, and MstProx, Ef1alpha 48D: Elongation factor 1 alpha 48D, Atpalpha: Sodium pump alpha subunit, Dad: daughter against dpp, alpha-Man-1: alpha-Mannosidase class 1a and Mthl2: methuselah-like 2.
