Figure 3 | Scientific Reports

Figure 3

From: Impaired Wnt signaling in dopamine containing neurons is associated with pathogenesis in a rotenone triggered Drosophila Parkinson’s disease model

Figure 3

Early modifications of signaling pathways in dopamine containing neurons in a rotenone induced PD model. (A) Shows up-regulated genes associated with MAPK/EGFR signaling pathway derived from the microarray data, and down-regulated genes associated with Wnt signaling pathway (B). qRT-PCR analysis of canonical target genes of the corresponding pathways (C–E). Spitz, a canonical target gene of the EGFR-pathway (C), Armadillo (arm) a central mediator of the wnt-pathway (D) and dad, a canonical TGF-β-pathway response gene (E). Ras85D: Ras Oncogene at 85D, Egfr: Epidermal growth factor receptor, RasGAP1: Ras GTPase activating protein 1, Rab14, Pk92B or DASK1: Protein kinase at 92B, drak: Death associated protein kinase related, skpA:skpA, CanA1: Calcineurin A1, smox: Smad on X, sgg: Shaggy: CycD: Cyclin D.

Back to article page