Table 1 Enriched functional categories for genes differentially regulated by rotenone.
Database identifier | Functional category (Enriched GO terms) | Number of changed genes | p-value < 0.05 |
|---|---|---|---|
Upregulated genes | |||
GO:0032535 | Regulation of cell size/Neurogenesis | 13 | 0.022 |
GO:0042981 | Apoptosis | 10 | 0.030 |
GO:0007568 | Ageing | 10 | 0.030 |
KEGG_PATHWAY | MAPK signaling pathway | 6 | |
KEGG_PATHWAY | mTOR signaling pathway | 4 | |
KEGG_PATHWAY | TGF beta signaling pathway | 5 | |
SM00034 | CLECT C-type | 6 | 0.040 |
GO:0007269 | Cell-cell signaling/neurotransmitter secretion | 15 | 0.040 |
GO:0000022 | Motor activity | 11 | 0.003 |
GO:0046146 | Tetrahydrobiopterin metabolic process | 4 | 0.012 |
Downregulated genes | |||
GO:0050877 | Neurological system processes | 20 | 0.014 |
KEGG_PATHWAY | Wnt signaling pathway | 6 | |
GO:0010564 | Regulation of cell cycle process | 6 | 0.024 |
GO:0009310 | Amine catabolic process | 4 | 0.040 |
