Figure 4

Dependence of dengue virus infection on CD42b. The cells from Fig. 3 were further analyzed. Intracellular DENV⁺ cells were firstly gated ((A) black eclipse) and then plotted in two-dimension of intracellular DENV and surface platelet receptors ((B) CD41, (C) CD42b). The cells were further gated to exclude the non-specific signal (black square). (D) Single-cell virus-protein analysis of intracellular DENV and surface CD41 (E) Single-cell virus-protein analysis of intracellular DENV and surface CD42b. r = Pearson correlation coefficient. p = p-value. n = the number of analyzed cells. Statistical significance was determined by using Fisher transformation test.