Figure 6

Proposed pathogenesis of platelet destruction and recovery in dengue patients. DENV might attack CD42b⁺ platelets and CD42b⁺ mature megakaryocytes leading to the rapid destruction of platelets. DENV could not attack CD42b⁻ early megakaryocytes explaining the characteristic delay of platelet recovery during the differentiation from early to mature megakaryocytes for 3 days. All new CD42b⁺ megakaryocytes could start producing platelets resulted in the rapid recovery of platelets.