Figure 7
From: Selective Tropism of Dengue Virus for Human Glycoprotein Ib
Proposed the strategy to stop the disease progression to severe dengue. Aedes aegypti inject DENV into human skin. Dendritic cells phagocytose and amplify DENV leading to viremia causing fever4,38,39. DENV in bloodstream may infect CD42b+ mature megakaryocytes and platelets leading to thrombocytopenia causing hemorrhage. DENV may also infect CD42b+ endothelial cells leading to plasma leakage causing shock. Inhibiting the binding of DENV to CD42b would be able to stop the disease progression from dengue fever to severe dengue.
