Figure 8
Picket-fence arrangement of neu on a HDL nanodisc. Stoichiometry of phospholipids, cholesterol and peptides was the following: 150:15:24 POPC:chol:neu. Left panels, side views; right panels, top-down views. (a) t = 0 μs. Peptides are initially placed on disc surface randomly. (b) t = 1 μs. 14 out of 24 peptides migrated to disc edge. (c) t = 2 μs. Peptides are initially arranged in a “picket-fence” orientation. Peptides are shown in red ribbons. POPC and cholesterol are represented as sticks: acyl chain, silver; nitrogen, blue, oxygen, red; phosphorus, orange balls; cholesterol carbons, black.
