Figure 8 | Scientific Reports

Figure 8

From: DYRK1A inhibition and cognitive rescue in a Down syndrome mouse model are induced by new fluoro-DANDY derivatives

Figure 8The alternative text for this image may have been generated using AI.

Mice were trained in a standard spatial learning protocol (MWM paradigm). (A) All mice showed a gradual improvement across training sessions. As expected, Ts65Dn mice showed a behavioral impairment (increased path lengths to reach the goal location as compared to WT mice). This deficit was partly corrected following treatment with 5a. (B) The same differences between groups were observed using pooled data over the 5 training sessions. Overall comparisons between groups: *p < 0.05; **p < .01; ***p < 0.001. Different from control (WT-Vehicle group): #p < 0.05; ##p < 0.01; ###p < 0.001.

Back to article page