Table 2 Chemical structures and bioactivities of NPD8716 and its analogs. IC50s for inhibiting HBV infection and NTCP-mediated bile acid uptake are shown on the second and the third columns, respectively. CC50s determined by MTT assay are also shown in the fourth column. IC50s and CC50s are shown in μM.

From: Chemical array system, a platform to identify novel hepatitis B virus entry inhibitors targeting sodium taurocholate cotransporting polypeptide

name & structure

IC50 (HBV infection)

IC50 (NTCP transporter)

CC50

NPD8716

238 ± 23.6

17.8 ± 1.1

>270

NPD3980

194 ± 22.7

34.9 ± 12.3

>270

NPD13325

145 ± 9.5

12.5 ± 1.5

>270

NPD4939

123 ± 7.4

16.2 ± 1.4

>270

NPD11375

150 ± 11.3

13.3 ± 1.9

>270

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