Table 1 The baseline characteristics of patients who developed acute respiratory distress syndrome (ARDS) (n = 59) or did not develop ARDS (n = 405) by day seven.
From: Receptor for advanced glycation end-products and ARDS prediction: a multicentre observational study
No ARDS (n = 405) | Develop ARDS (n = 59) | p-value | |
|---|---|---|---|
Age (years) | 61 ± 16 | 62 ± 16 | 0.5 |
Male sex | 267 (66) | 46 (78) | 0.07 |
Race/ethnicity | 0.2 | ||
- White | 389 (96) | 54 (92) | |
- Black | 12 (3) | 4 (7) | |
- Asian | 4 (1) | 1 (1) | |
Body mass index (kg/m2) | 26.6 ± 6.2 | 26.9 ± 6.5 | 0.9 |
Primary admission diagnosis | |||
- Cardiac | 8 (2) | 2 (3) | 0.6 |
- Respiratory | 251 (62) | 38 (65) | 0.6 |
- Gastrointestinal | 69 (17) | 11 (17) | 0.9 |
- Infectious | 117 (29) | 22 (37) | 0.2 |
- Neurological | 56 (14) | 9 (15) | 0.8 |
- Major surgery | 101 (25) | 14 (23) | 0.7 |
- Other | 20 (5) | 2 (3) | 0.7 |
Coexisting chronic conditions | |||
- Atherosclerosis | 89 (22) | 15 (25) | 0.6 |
- Diabetes | 73 (18) | 8 (14) | 0.5 |
- Hypertension | 162 (40) | 27 (46) | 0.5 |
- Dyslipidemia | 85 (21) | 15 (25) | 0.5 |
- Current smoking | 101 (25) | 19 (32) | 0.3 |
- Asthma | 12 (3) | 2 (3) | 0.9 |
- COPD | 41 (10) | 10 (17) | 0.2 |
- Chronic renal failure requiring dialysis | 12 (3) | 1 (2) | 0.7 |
- Liver cirrhosis | 20 (5) | 2 (3) | 0.8 |
- Cancer | 77 (19) | 14 (22) | 0.6 |
ARDS risk factor | |||
- Shock | 101 (25) | 16 (27) | 0.8 |
- Sepsis | 113 (28) | 20 (34) | 0.3 |
- Pneumonia | 126 (31) | 29 (49) | 0.1 |
- Aspiration | 24 (6) | 5 (8) | 0.9 |
- Severe trauma | 41 (10) | 5 (8) | 0.9 |
- Pancreatitis | 24 (6) | 23 (5) | 0.9 |
- Drug overdose | 32 (8) | 4 (6) | 0.7 |
- High-risk surgery | 89 (22) | 9 (14) | 0.8 |
Lung Injury Prediction Score (LIPS) | 4.9 ± 2.4 | 5.7 ± 2.8 | 0.07 |
Simplified Acute Physiology Score II | 43 ± 19 | 49 ± 18 | 0.01 |
Vasopressor use at admission | 93 (23) | 17 (29) | 0.5 |
Invasive ventilation at admission | 186 (46) | 34 (58) | 0.09 |
Noninvasive ventilation at admission | 28 (7) | 3 (5) | 0.8 |
30-day mortality | 49 (12) | 11 (19) | 0.003 |
