Figure 4 | Scientific Reports

Figure 4

From: In vivo GluCEST MRI: Reproducibility, background contribution and source of glutamate changes in the MPTP model of Parkinson’s disease

Figure 4

GluCEST MRI and 1H MRS in the striatum. (a) GluCEST contrast was found to be higher in the striatum of the MPTP group (26.2 ± 0.8%, n = 19) compared to the control group (23.3 ± 1.0%, n = 16; p ≤ 0.001). (b) Glutamate measured via 1H MRS in the striatum was also found to be higher in the MPTP group (control: 12.3 ± 1.0 mM, n = 16; MPTP: 14.4 ± 1.1 mM, n = 19; p ≤ 0.005).

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