Table 1 IgG1-immunoreactive proteins from Cryptococcus neoformans.

14-3-3 protein, putative (29.0 kDa; Q5K8Z6)

1 (#16)

^aRecognized as an antigen in mice infected with C. neoformans H99γ and in C. gattii infection in humans and koalas.

^cAntibodies against this protein are induced in the course of the natural infection of schistosomiasis.

^13,15,26,52

Elongation factor 1-beta (24.4 kDa; Q5KKD1)

1 (#15)

^aRecognized as an antigen in patients with cryptococcosis caused by C. gattii and as a non-specific antigen in C. gattii infection in koalas.

^15,26

Expressed protein Q5K7Y6 (14.9 kDa; Q5K7Y6)

1 (#35)

Not reported to date

Glyceraldehyde-3-phosphate dehydrogenase (36,308 kDa; J9VRH1)

1 (#44)

^aRecognized as an antigen in patients with cryptococcosis caused by C. gattii.

^b Immunoreactive protein identified in mice inoculated with Candida albicans and in sera from patients with paracoccidioidomycosis.

^bThis protein appeared not to be a suitable target for the development of immunotherapeutic strategies against candidiasis, despite being an immunodominant component that induces antibody response against C. albicans.

^bThe most abundant allergen from Aspergillus fumigatus in human sera.

^cCommon immunogenic antigen among Eimeria species. This protein was evaluated in form of DNA vaccine, which induced effective protection against single and mixed infection of these species.

^cAntibodies against this protein are induced in infection of schistosomiasis. This protein is considered a target of protective immunity in humans against Schistosoma mansoni and S. haematobium.

^{19,26,53,54,55,56,57}

Hsp71-like protein (69.6 kDa; J9VZ70)

1 (#19)

^a70-kD Hsp family from C. neoformans described as a major target molecule of the humoral response in mice.

^aHsp70 recognized as an antigen in mice infected with C. neoformans H99γ and C. gattii.

^aHsp70 identified as immunodominant protein in mice immunized with C. gattii cell wall and cytoplasmic protein preparations.

^{13,14,15,23,26,37,58}

Hsp72-like protein (69,513; J9VU43)

1 (#20)

^a70-kD Hsp family from C. neoformans described as a major target molecule of the humoral immune response in mice.

³⁷

Phosphopyruvate hydratase (Enolase) (47.7 kDa; Q5KLA7)

2 (#11, #12)

^aRecognized as an antigen in mice infected with C. neoformans H99γ and in C. gattii infection in humans and koalas.

^aImmunodominant protein identified in mice immunized with C. gattii cell wall and cytoplasmic protein preparations.

^bStimulates protective IgG2a in sera from vaccinated mice with systemic candidiasis.

^bA major antigen of fungal infection (A. fumigatus and C. albicans)

^{13,14,15,23,26,39,59}

Thioredoxin-dependent peroxide reductase (21.6 kDa; Q5KEB3)

1 (#47)

Not reported to date

¹⁵

Transaldolase (35.3 kDa; Q5K952)

4 (#30–32, #43, #46)

^aRecognized as an antigen in mice infected with C. neoformans H99γ.

^aImmunodominant protein identified in mice immunized with C. gattii cell wall protein preparations.

^bIdentified as an allergen of Fusarium proliferatum and Cladosporium and Penicillium species.

^13,23,60,61

Uncharacterized protein J9W025 (14.8 kDa; J9W025)

2 (#36, #37)

Not reported to date.