Table 2 IgG2a-immunoreactive proteins from Cryptococcus neoformans.

From: Identification of T helper (Th)1- and Th2-associated antigens of Cryptococcus neoformans in a murine model of pulmonary infection

Protein (MW; UniProt ID)

Number of isoforms (spot #)

Immunological characteristics previously reporteda,b

Ref.

C. neoformans -specific

 Hsp60-like protein (61.4 kDa; J9VJ21)

1 (#40)

bVaccination with recombinant Hsp60 protects mice against a lethal intravenous inoculum of Histoplasma capsulatum yeast cells.

bIgG1 and IgG2a monoclonal antibodies significantly prolonged the survival of mice infected with H. capsulatum.

40,43

 Phosphoglucomutase (60.5 kDa; J9W313)

2 (#2, #21)

bRecognized as an antigen in A. fumigatus.

39

 Pyruvate decarboxylase (67.6 kDa; J9VTH3)

1 (#3)

bStimulates protective IgG2a in sera from vaccinated mice with systemic candidiasis.

bRecognized as an antigen of Aspergillus fumigatus.

39,59

C. neoformans -unspecific

 ATP synthase subunit beta (58.7 kDa; J9VPP7)

5 (#24–26, #33–34)

aRecognized as an antigen in mice infected with C. neoformans H99γ, an antigen in humans infected with C. gattii and as a non-specific antigen in C. gattii infection in koalas.

14,15,26

  1. Four cryptococcal immunogenic proteins were identified to react specifically with IgG2a antibodies. Three of them were determined as C. neoformans-specific and one was regarded as C. neoformans-unspecific, as it reacted strongly with sera from naïve wild type, IL-12- and IL-4Rα-deficient mice.
  2. MW: Molecular weight; UniProt ID: Identification number in the UniProt database infec.: infected.
  3. aDescribed in proteomics studies of cryptococcosis and bother mycoses.
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