Table 3 Cryptococcus neoformans proteins immunoreactive with both, IgG1 and IgG2a antibodies.

From: Identification of T helper (Th)1- and Th2-associated antigens of Cryptococcus neoformans in a murine model of pulmonary infection

Protein (MW; UniProt ID)

Number of isoforms (spot #)

Immunological characteristics previously reporteda,b

Ref.

Hsp90-like protein (79.2 kDa; J9VVA4)

1 (#18)

aHsp90 recognized as an antigen in mice infected with C. neoformans H99γ.

bA major antigen of A. fumigatus.

13,14,39

Spermidine synthase, putative (82.4 kDa; Q5KEA8)

4 (#4–7)

Not reported to date.

 

Uncharacterized protein J9VHM5 (73.0 kDa; J9VHM5)

1 (#17)

Not reported to date.

 
  1. Three cryptococcal immunogenic proteins were identified to react with both IgG1 and IgG2a antibodies from mice infected with C. neoformans. Immunological characteristics of the proteins or protein family compared to previous studies of fungal infections, including cryptococcosis, are given.
  2. MW: Molecular weight.
  3. UniProt ID: Identification number in the UniProt database.
  4. aDescribed in proteomics studies of cryptococcosis, and bother mycoses.
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