Table 2 Functional enrichment analysis of common genes by GO-terms.
From: RNA-seq transcriptome analysis of breast cancer cell lines under shikonin treatment
Term | Category | Number of genes | % | P value | Genes |
|---|---|---|---|---|---|
Response to unfolded protein | B.P. | 5 | 1.57 | 1.2 × 10−5 | HSPH1, HSPA6, HSPA1A, DNAJB1, HSPA1B, PPP1R15A |
Negative regulation of apoptosis | B.P. | 6 | 1.89 | 6.7 × 10−4 | CDKN1A, HMOX1, BAG3, PIM1, UBC, HSPA1A |
Negative regulation of programmed cell death | B.P. | 6 | 1.89 | 7.2 × 10−4 | CDKN1A, HMOX1, BAG3, PIM1, UBC, HSPA1A, HSPA1B |
Negative regulation of cell death | B.P. | 6 | 1.89 | 7.2 × 10−4 | CDKN1A, HMOX1, BAG3, PIM1, UBC, HSPA1A, HSPA1B |
Positive regulation of anti-apoptosis | B.P. | 3 | 0.94 | 1.6 × 10−3 | CDKN1A, DUSP1, HMOX1 |
Intracellular part | C.C. | 25 | 7.86 | 3.2 × 10−3 | HSPA1A, HSPA1B, SESN2, HSPH1, TSPYL2, SLC25A25, MAP1LC3B, HMOX1, BAG3, ETAA1, SIK1, MAFF, ARC, PIM1, MAP1LC3B2, SNAI1, RND3, CDKN1A, DUSP2, ATF3, DUSP1, CSRNP1, ZFAND2A, UBC, DNAJB1, PPP1R15A |
Regulation of cell cycle | B.P. | 5 | 1.57 | 4.3 × 10−3 | CDKN1A, TSPYL2, GADD45G, PIM1, SIK1 |
Regulation of programmed cell death | B.P. | 7 | 2.20 | 5.2 × 10−3 | CDKN1A, DUSP1, HMOX1, BAG3, PIM1, UBC, HSPA1A, HSPA1B |
Regulation of cell death | B.P. | 7 | 2.20 | 5.3 × 10−3 | CDKN1A, DUSP1, HMOX1, BAG3, PIM1, UBC, HSPA1A, HSPA1B |
Regulation of transferase activity | B.P. | 5 | 1.57 | 6.5 × 10−3 | CDKN1A, TSPYL2, DUSP2, GADD45G, PIM1 |
Apoptosis | B.P. | 6 | 1.89 | 6.8 × 10−3 | BAG3, CSRNP1, GADD45G, UBC, TNFSF9, PPP1R15A |
Intracellular membrane-bounded organelle | C.C. | 21 | 6.60 | 7.3 × 10−3 | MAFF, ARC, PIM1, HSPA1A, HSPA1B, SESN2, SNAI1, RND3, CDKN1A, TSPYL2, ATF3, DUSP2, DUSP1, SLC25A25, MAP1LC3B, HMOX1, ZFAND2A, CSRNP1, UBC, DNAJB1, SIK1, PPP1R15A |
Nucleus | C.C. | 16 | 5.03 | 8.2 × 10−3 | MAFF, PIM1, HSPA1A, HSPA1B, SESN2, SNAI1, CDKN1A, TSPYL2, DUSP2, ATF3, DUSP1, HMOX1, ZFAND2A, CSRNP1, UBC, DNAJB1, SIK1 |
Intracellular organelle | C.C. | 22 | 6.92 | 1.2 × 10−2 | MAFF, ARC, PIM1, HSPA1A, MAP1LC3B2, HSPA1B, SESN2, SNAI1, RND3, CDKN1A, TSPYL2, ATF3, DUSP2, DUSP1, SLC25A25, MAP1LC3B, HMOX1, ZFAND2A, CSRNP1, UBC, DNAJB1, SIK1, PPP1R15A |
Negative regulation of cell growth | B.P. | 3 | 0.94 | 1.5 × 10−2 | CDKN1A, TSPYL2, OSGIN1 |
Negative regulation of cellular process | B.P. | 9 | 2.83 | 1.5 × 10−2 | CDKN1A, TSPYL2, HMOX1, BAG3, PIM1, UBC, OSGIN1, HSPA1A, HSPA1B, SIK1 |
Regulation of phosphorus metabolic process | B.P. | 5 | 1.57 | 1.6 × 10−2 | CDKN1A, TSPYL2, DUSP2, GADD45G, PIM1 |
Negative regulation of cell size | B.P. | 3 | 0.94 | 1.7 × 10−2 | CDKN1A, TSPYL2, OSGIN1 |
Negative regulation of catalytic activity | B.P. | 4 | 1.26 | 1.8 × 10−2 | CDKN1A, DUSP2, GADD45G, UBC |
Cell cycle arrest | B.P. | 3 | 0.94 | 1.8 × 10−2 | CDKN1A, SESN2, PPP1R15A |
Cytoplasm | C.C. | 19 | 5.97 | 2.1 × 10−2 | ARC, PIM1, HSPA1A, MAP1LC3B2, HSPA1B, SESN2, RND3, HSPH1, CDKN1A, TSPYL2, SLC25A25, MAP1LC3B, HMOX1, ZFAND2A, BAG3, UBC, ETAA1, DNAJB1, SIK1, PPP1R15A |
Negative regulation of growth | B.P. | 3 | 0.94 | 2.1 × 10−2 | CDKN1A, TSPYL2, OSGIN1 |
Cellular protein metabolic process | B.P. | 10 | 3.14 | 3.9 × 10−2 | DUSP2, DUSP1, MAP1LC3B, BAG3, GADD45G, PIM1, UBC, MAP1LC3B2, DNAJB1, SIK1 |
