Table 3 KEGG enrichment analysis of common genes after shikonin treatment by MCF-7, SK-BR-3 and MDA-MB-231 cells.
From: RNA-seq transcriptome analysis of breast cancer cell lines under shikonin treatment
Pathway | P value (−log10) | Genes |
|---|---|---|
MAPK signaling pathway | 5.96 | HSPA1B,HSPA1A,HSPA6,GADD45G,DUSP1,DUSP2 |
P53 signaling pathway | 3.98 | CDKN1A,GADD45G,SESN2 |
Antigen processing and presentation | 3.67 | HSPA1B,HSPA1A,HSPA6 |
Spliceosome | 3.22 | HSPA1B,HSPA1A,HSPA6 |
Bladder cancer | 2.85 | CDKN1A,PGF |
Endocytosis | 2.78 | HSPA1B,HSPA1A,HSPA6 |
HIF1 signaling pathway | 2.09 | CDKN1A,HMOX1 |
Cell cycle | 1.93 | CDKN1A,GADD45G |
Pathways in cancer | 1.19 | CDKN1A,PGF |
PI3K-AKT signaling pathway | 1.15 | CDKN1A,PGF |
