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Figure 1

From: Vascular dysfunction in obese diabetic db/db mice involves the interplay between aldosterone/mineralocorticoid receptor and Rho kinase signaling

Figure 1

Plasma aldosterone, insulin and glucose concentrations and Nr3c2 and Sgk1 levels in arteries from db/db versus db/+ mice. (A) Plasma aldosterone levels are increased in db/db. MR antagonist treatment has no effect. Non fasting plasma levels of insulin (B) and glucose (C) are increased in db/db vs db/+ mice, and fasudil reduces both in db/db, but not in db/+. Nr3c2 (D) and Sgk1 (E) mRNA levels are increased in mesenteric arteries from db/db vs db/+ mice. MR antagonist treatment abolished increased Sgk1, but not Nr3c2 mRNA levels in mesenteric arteries from db/db versus db/+ mice. Ubc was used as housekeeping gene for normalization. Results are expressed mean ± SEM, n = 6–8 mice per group, **p < 0.01, ***p < 0.001 db/db vs db/+, †p < 0.05, ††p < 0.01 vehicle vs +MRA. MRA: MR antagonist (canrenoate); Nr3c2: nuclear receptor subfamily 3 group C member 2 (mineralocorticoid receptor); vs: versus. Vehicle: saline NaCl 0.9%; Ubc: ubiquitin C.

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