Figure 4 | Scientific Reports

Figure 4

From: Vascular dysfunction in obese diabetic db/db mice involves the interplay between aldosterone/mineralocorticoid receptor and Rho kinase signaling

Figure 4

Rho kinase activity is increased in mesenteric arteries from db/db versus db/+ mice. (A) Rho kinase activity was assessed by enzymatic immunoassay. Upregulation of downstream targets of Rho kinase activation with Mypt-1 (B) and Mlc (C) phosphorylation in db/db vs db/+ mice. (d) PKG-1α protein levels are decreased in mesenteric arteries from db/db vs db/+ mice. These changes were prevented by canrenoate treatment. Results are expressed as mean ± SEM, n = 6–8 mice per group, *p < 0.05, **p < 0.01 db/db vs db/+, †p < 0.05 vehicle vs +MRA. Vehicle: saline NaCl 0.9%.

Back to article page