Figure 7 | Scientific Reports

Figure 7

From: Vascular dysfunction in obese diabetic db/db mice involves the interplay between aldosterone/mineralocorticoid receptor and Rho kinase signaling

Figure 7

Hypothetical scheme of putative signaling mechanisms induced by aldosterone/MR over-activation in obesity. On one hand, aldosterone/MR induces ROCK activity through decreased PKG-1a, resulting in vascular hypercontractility of arteries from obese db/db mice. In obesity-related diabetes, ROCK may also contribute to vascular insulin resistance independently of MR. In addition, vascular remodeling, due to increased pro-fibrotic and pro-inflammatory signaling, is also regulated, in part, by MR. MLC: myosin light chain; Mypt1: myosin light chain phosphatase subunit 1; MR: mineralocorticoid receptor; PKG-1α: cGMP-dependent protein kinase G type 1 isoform alpha; ROCK: Rho kinase; p: phosphorylated.

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