Figure 1 | Scientific Reports

Figure 1

From: In Silico Non-Homologous End Joining Following Ion Induced DNA Double Strand Breaks Predicts That Repair Fidelity Depends on Break Density

Figure 1

(a) The average misrepair of DSBs as a fraction of total DSBs joined at 24 hours at a range of LETt for protons (p), alphas (α), and carbon-126+ (C). A dose independent difference in misrepair between iso-LETt ions is shown. Carbon-126+ shows anomalous behaviour between LETt of 20–30 keV/µm, discussed later. Error bars show the standard error in the mean between 200 repeat simulations. Lines show second order polynomial fits to guide the eye. (b) The DSB separation probability density function for iso-LETt protons (p), alpha (α), and carbon-126+ (C) in a 5 µm diameter spherical nucleus. The distributions show the probability that another DSB is located at a given separation from any DSB. Differences are only seen at small separations (inset), due to separations between intra-track DSBs. (c) The DSB end displacement at 24 hours. Showing that 95% of DSB ends move 168 nm or less in 24 hours. This limits DSB interactions to nearby neighbours where the DSB separation distribution is different between the ions.

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