Figure 5

Correlation with ALDH genotyping, expression and other mitochondria-associated proteins. (a) Downregulation of ALDH2 is generally observed between wild types (rs671 GG) and heterozygotes (rs671 GA). Data from the Taipei Veteran’s General Hospital cohort. Y-axis denotes the reads per kilobase of exon model per million mapped reads (RPKM) value. (b) Expression of candidate genes (baseline) with functional group annotations (top) for mitochondria matrix proteins are shown among the 5 cancers. (c) Mitochondrial TOM complex. BRCA: breast cancer, LUSC: lung squamous cell carcinoma, LUAD: lung adenocarcinoma, HNSC: head and neck squamous cell carcinoma, ESSC: esophageal squamous cell carcinoma, case-control: all tumor vs. normal, pair: pairwise tumor vs. normal. All p-values > 0.05 were marked with an asterisk (*).