Figure 2 | Scientific Reports

Figure 2

From: The NLRP3 Inflammasome May Contribute to Pathologic Neovascularization in the Advanced Stages of Diabetic Retinopathy

Figure 2

Akimba retina displayed reduced retinal thickness and disrupted retinal function. Optical coherence tomography (OCT) analysis showed disruption of retinal architecture and appearance of subretinal hemorrhage in (C) Kimba and (D) Akimba retina. This was accompanied by a significant reduction in retinal thickness in these mice (E). Abnormal ERG was observed in all the mice models (F–H), with significantly decreased scotopic a-wave (G) and b-wave (H) amplitudes. Akimba mice showed the most severe disruption of retinal function, corresponding with the loss of retinal thickness and subretinal hemorrhages. n = 6 animals in each group. ***p < 0.001 compared to WT. Data represent mean \(\pm \) SD. Scale bar, 50 µm.

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