Figure 8
Pro-angiogenic factors were upregulated in Akimba retina. mRNA expression of VEGF showed a 3-fold increase in Akimba mouse (A), corresponding with a >2-fold increase in protein expression seen in Western blot (B, E). Similarly, ICAM-1 was elevated (B, D) up to 15-fold in Kimba and 25-fold in Akimba mice. PECAM-1 showed an upward trend but was not statistically significant in any of the mouse models studied (B, C). n = 4 retina per group for qPCR and western blot; repeated twice. *p < 0.05; **p < 0.01 and ***p < 0.001 compared to WT. Data represent mean \(\pm \) SD.
