Figure 9 | Scientific Reports

Figure 9

From: Remodeling of the Actin/Spectrin Membrane-associated Periodic Skeleton, Growth Cone Collapse and F-Actin Decrease during Axonal Degeneration

Figure 9

The axonal cytoskeleton during developmental pruning. For most of the degeneration period (3–18 hours after TFW) growth cones collapse, and the MPS loses organization and its abundance decreases by ~50%. At the same time, microtubules get enriched in detyrosinated tubulin. During fragmentation, the MPS is lost, but βII-spectrin and F-actin are still present. When fragments become round beads-like structures, βII-spectrin and F-actin are almost absent, while they continue to be positive to markers of microtubules.

Back to article page