Figure 1 | Scientific Reports

Figure 1

From: Enhanced viral-mediated cochlear gene delivery in adult mice by combining canal fenestration with round window membrane inoculation

Figure 1

Inner ear schematic showing the RWM injection and the RWM + CF injection. Surgical approach for the RWM + CF injection. (a–c) Schematic diagram showing the anatomy of the inner ear (a), and the RWM (b) and RWM + CF (c) surgical approaches. Green dotted and solid lines indicate the predicted flow of injected vectors. Sv: scala vestibuli, Sm: scala media, St: scala tympani, OW: oval window, RW: round window, CA: cochlea aqueduct. (d–g) Surgical pictures showing the RWM + CF approach. Arrowheads indicate the hole in the PSCC before (f) and after (g) the inoculation. Arrows outline the glass pipette. EAC: external auditory canal, FN: facial nerve, SCM: sternocleidomastoid muscle, OB: otic bulla, SA: stapedial artery, D: dorsal, A: anterior.

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