Figure 3 | Scientific Reports

Figure 3

From: Characterization of Retinal Ganglion Cell and Optic Nerve Phenotypes Caused by Sustained Intracranial Pressure Elevation in Mice

Figure 3

ICP elevation causes optic nerve swelling, hyperemia, and loss of physiologic cupping. Representative fundus and SD-OCT images taken from the same animal before and after 2 weeks of ICP elevation. Fundus photos are cropped to show the region including the optic nerve that is reflected in the corresponding OCT scans. ICP before: (a) Fundus photography shows a representative optic disc with clear margins, normal coloration, and surrounding blood vessels of normal caliber; (b) SD-OCT shows physiological cupping (asterisk). ICP after: (c) Fundus photography shows the same optic disc, now with blurred margins, hyperemic discoloration, and engorged surrounding blood vessels; (d) SD-OCT shows a loss of physiological cupping and anterior displacement of the optic disc.

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