Table 3 Relative HIF-1α intensity in each retinal layer.

From: Characterization of Retinal Ganglion Cell and Optic Nerve Phenotypes Caused by Sustained Intracranial Pressure Elevation in Mice

 

GCL

IPL

INL

OPL

ONL

Sham

1 ± 0.17

1 ± 0.16

1 ± 0.15

1 ± 0.27

1 ± 0.19

Elevated ICP

2.21 ± 0.37

1.19 ± 0.09

1.32 ± 0.29

1.26 ± 0.3

2.09 ± 0.86

  1. Normalized intensity is expressed as mean ± SEM. N = 4 sections from 4 eyes in each group. After 2 weeks, Sham and ICP elevation eyes were assessed with antibody to HIF-1α and the mean normalized staining intensity compared with a t-test. The only statistically significant difference detected in any retinal layer was in the GCL (bold, p = 0.042). HIF = hypoxia-inducible factor; ICP = intracranial pressure; GCL = retinal ganglion cell layer; IPL = inner plexiform layer; INL = inner nuclear layer; OPL = outer plexiform layer; ONL = outer nuclear layer.
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