Figure 10

(a) Comparative illustration of rotamer toggling (distribution of χ dihedral angles) observed at the conserved regions of C5aR complexed to agonist ^hC5a and engineered antagonist ^hC5a(A8) with respect to the other active-inactive pair of GPCRs^{41,42,43,61,62,63,64,65}. (b) Comparison of rotamer toggling observed in C5aR on binding to ^hC5a with respect to free unbound C5aR. Rotamer toggling for F^6.44, W^6.48 of “transmission switch” and Y^7.53 of “tyrosine toggling switch” are illustrated. Active GPCRs are marked in asterisk. C5aR^I: free or unbound C5aR; C5aR: bound to ^hC5a(A8); C5aR*: bound to ^hC5a.