Figure 5 | Scientific Reports

Figure 5

From: The Model Structures of the Complement Component 5a Receptor (C5aR) Bound to the Native and Engineered hC5a

Figure 5

(a) Illustration of “two-site” binding in the model complex of hC5a(A8)-C5aR inserted into the POPC bilayer. (b) Interaction map of hC5a(A8) illustrating the “hot-spot” residues, respectively at the “site1” and “site2” of C5aR. “Hot-spot” residues that are known to modulate both binding and signaling upon mutation are highlighted in red. Residues of hC5a(A8) whose mutation are known in hC5a are shown in red and underlined.

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