Table 3 Antimalarial activity of MCM-41 encapsulated QN (1) in P. berghei NK65-infected mice.
From: Mesoporous silica nanocarriers encapsulated antimalarials with high therapeutic performance
Dose (mg/kg bw) | Parasitemia (% Reduction) | Mean Survival Time (Days) | ||
|---|---|---|---|---|
Day 4 post-inoculation | Day 6 post-inoculation | Day 8 post-inoculation | ||
Infected Untreated | 2.81 | 3.51 | 9.60 | 7.75 |
QN1 (15) | 0.90(68.14) | 0.97(65.48) | 2.30(76.06) | 20.50 |
0.0625 | 0.25(91.10) | 0.38(89.47) | 0.85(90.71) | 16.67 |
0.125 | 0.02(99.18) | 0.07(98.03) | 0.12(99.50) | 23.33 |
0.25 | 0.40(85.65) | 0.69(80.83) | 0.89(90.25) | 26.67 |
0.50 | 0.14(95.12) | 0.54(84.93) | 0.52(94.33) | 21.67 |
1.00 | 0.48(82.77) | 0.42(88.28) | 0.31(96.61) | 18.00 |
