Table 6 Antimalarial activity of aMCM-41 encapsulated ATS (4) in P. berghei NK 65-infected mice.
From: Mesoporous silica nanocarriers encapsulated antimalarials with high therapeutic performance
Dose (mg/kg bw) | Parasitemia (% Reduction) | Mean Survival Time (Days) | ||
|---|---|---|---|---|
Day 4 post-inoculation | Day 6 post-inoculation | Day 8 post-inoculation | ||
Infected Untreated | 2.81 | 3.61 | 9.60 | 7.75 |
ATS4 (5) | 0.45(83.99) | 0.68(81.16) | 2.04(78.75) | 13.50 |
0.0625 | 2.73(2.85) | 1.16(67.87) | 4.85(49.48) | 15.75 |
0.125 | 0.09(96.80) | 4.99(38.23) | 5.43(43.44) | 13.50 |
0.25 | 0.86(69.40) | 2.24(37.95) | 7.65(20.31) | 18.25 |
0.50 | 0.81(71.17) | 1.76(51.25) | 8.54(11.04) | 16.50 |
1.00 | 0.00(100) | 1.47(59.28) | 0.56(94.17) | 9.00 |
