Table 2 Summary of effect of cinacalcet on biochemical parameters.
Outcomes | subgroup | No of patients (studies) | RR or SMD [95% CI] | p for RR or SMD | heterogeneity I2% (p) | effects model | heterogeneity for subgroup I2% (p) | RIS | Description of TSA graph: cumulative Z curve crossed the TSA boundaries |
|---|---|---|---|---|---|---|---|---|---|
PTH reduction ≥ 30% | all | 3683 (14) | 2.46 [1.59, 3.81] | <0.0001 | 95 (<0.00001) | random | 0 (0.76)a | 2092 | yes |
dialysis | 3237 (12) | 2.42 [1.48, 3.97] | 0.0004 | 96 (<0.00001) | random | 2403 | yes | ||
none of two | 446 (2) | 2.65 [1.96, 3.58] | <0.00001 | 0 (0.76) | random | NA | NA | ||
achieved serum PTH target | all | 3589 (13) | 3.03 [1.78, 5.17] | <0.0001 | 94 (<0.00001) | random | 83.5 (0.01)a | 2293 | yes |
dialysis | 3197 (12) | 2.74 [1.61, 4.67] | 0.0002 | 93 (<0.00001) | random | 2294 | yes | ||
none of two | 392 (1) | 10.98 [4.17, 28.92] | <0.00001 | NA | random | NA | NA | ||
end of treatment serum PTH | all | 3100 (12) | −0.67 [−0.90, −0.44] | <0.00001 | 88 (<0.00001) | random | 0 (0.65) | 1272 | yes |
dialysis | 2785 (10) | −0.68 [−0.95, −0.41] | <0.00001 | 90 (<0.00001) | random | 0 (0.84)a | 1370 | yes | |
renal transplant | 114 (1) | −0.50 [−0.88, −0.13] | 0.008 | NA | random | 0 (0.44)b | NA | NA | |
none of two | 201 (1) | −0.73 [−1.04, −0.41] | <0.00001 | NA | random | 0 (0.38)c | NA | NA | |
end of treatment serum calcium (Ca) | all | 2623 (14) | −1.07 [−1.30, −0.84] | <0.00001 | 84 (<0.00001) | random | 93.5 (<0.00001) | 399 | yes |
dialysis | 2176 (11) | −0.93 [−1.13, −0.74] | <0.00001 | 73 (0.0001) | random | 0 (0.5)a | 314 | yes | |
renal transplant | 114 (1) | −2.41 [−2.90, −1.92] | <0.00001 | NA | random | 96.7 (<0.00001)b | NA | NA | |
none of two | 333 (2) | −1.13 [−1.66, −0.60] | <0.0001 | 58 (0.12) | random | 91.8 (0.0005)c | NA | NA | |
end of treatment serum phosphorous (P) | all | 3366 (14) | −0.03 [−0.24, 0.17] | 0.75 | 86 (<0.00001) | random | 97.4 (<0.00001) | 51194 | no |
dialysis | 2918 (11) | −0.21 [−0.29, −0.14] | <0.00001 | 26 (0.20) | fixed | 96.9 (<0.00001)a | 1937 | yes | |
renal transplant | 114 (1) | 1.28 [0.88, 1.69] | <0.00001 | NA | random | 98 (<0.00001)b | NA | NA | |
none of two | 334 (2) | 0.53 [0.29, 0.77] | <0.0001 | 0 (0.83) | fixed | 90 (0.002)c | NA | NA | |
end of treatment calcium by phosph- orous product (Ca*P) | all | 3005 (11) | −0.49 [−0.67, −0.32] | <0.00001 | 77 (<0.00001) | random | 97 (<0.00001)a | 2606 | yes |
dialysis | 2613 (10) | −0.57 [−0.65, −0.49] | <0.00001 | 9 (0.36) | fixed | 293 | yes | ||
none of two | 392 (1) | 0.15 [−0.08, 0.38] | <0.00001 | NA | random | NA | NA | ||
Achieved (Ca*P) target | dialysis | 1223 (5) | 1.33 [1.20, 1.47] | <0.00001 | 45 (0.12) | fixed | 1470 | yes |
